GLP-1 Titration Calculator

A titration schedule is the recommended plan for gradually increasing your GLP-1 medication dose over time. Starting low and increasing slowly helps your body adjust and reduces gastrointestinal side effects like nausea. Each medication has an FDA-recommended escalation timeline, typically increasing every four weeks.

GLP-1 receptor agonists work by slowing gastric emptying and affecting appetite signals. Starting at the full dose can cause significant nausea, vomiting, and other GI side effects. Gradual titration allows your body to adapt, improving tolerability and long-term adherence to the medication.

Extended titration adds four extra weeks to each dose step, giving your body more time to adjust before increasing. This is common when patients experience persistent side effects at a new dose level. Your prescriber may recommend this approach if standard four-week intervals feel too aggressive.

Yes. Many patients achieve their clinical goals before reaching the maximum dose. For example, some semaglutide patients stabilize at 1.0 mg rather than escalating to 2.4 mg. Use the custom target dose option to see what your schedule looks like at a lower endpoint. Always discuss dose decisions with your provider.

Compound GLP-1 medications are typically drawn up using U-100 insulin syringes, where 100 units equals 1 mL. The conversion depends on your vial concentration: units = (dose in mg / concentration in mg per mL) x 100. This calculator handles that math for you at every titration step.

Standard titration takes about 16 weeks for Wegovy (semaglutide) and 20 weeks for Mounjaro or Zepbound (tirzepatide). Extended titration adds four weeks per step, roughly doubling the timeline. Your actual schedule depends on tolerability and your prescriber's guidance.

No. This calculator is for educational and planning purposes only. It displays FDA-recommended titration schedules and converts doses to injection units based on your vial concentration. It does not constitute medical advice. Dosage calculations should always be verified by a healthcare professional.

No. All calculations run entirely in your browser. Your medication details, concentration, and results are never sent to a server or stored. You can use this tool as often as you like with complete privacy.