Yini i-Phenoxybenzamine: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Phenoxybenzamine iyimithi kadokotela evimba izimpawu ezithile zemizwa emzimbeni wakho, ikakhulukazi iqondise ama-alpha receptors. Isetshenziswa ikakhulu ukuphatha umfutho wegazi ophezulu obangelwa imithombo engavamile ebizwa ngokuthi ama-pheochromocytomas, akhulula i-adrenaline eningi kakhulu egazini lakho. Le mithi isebenza ngokukhulula imithambo yegazi futhi isize inhliziyo yakho ukuba ipompe ngempumelelo enkulu, okwenza kube lula ngomzimba wakho ukugcina amazinga omfutho wegazi anempilo.

Yini i-Phenoxybenzamine?

I-Phenoxybenzamine ingeyodwa yezinhlobo zemithi ebizwa ngokuthi ama-alpha-blockers noma ama-alpha-adrenergic blocking agents. Cabanga ngayo njengomlawuli wethrafikhi opholile wemithambo yakho yegazi, ebasiza ukuba bahlale bekhululekile futhi bevulekile. Le mithi isetshenziswe ngokuphepha amashumi eminyaka futhi ithathwa njengendlela yokwelapha yegolide yezimo ezithile ezingavamile ezibangela ukunyuka okuyingozi komfutho wegazi.

Umuthi uza ngesimo samaphilisi futhi uvame ukuthathwa ngomlomo. Kuyidakamizwa elisebenza isikhathi eside, okusho ukuthi lihlala ohlelweni lwakho isikhathi eside, linikeza ukulawulwa komfutho wegazi okuzinzile usuku lonke. Udokotela wakho uzokunika lo muthi kuphela uma ezinye izindlela zokwelapha zingafaneleki noma zingasebenzi esimweni sakho esithile.

Isetshenziselwani i-Phenoxybenzamine?

I-Phenoxybenzamine ikakhulu inikezwa ukwelapha umfutho wegazi ophezulu obangelwa ama-pheochromocytomas kanye nama-paragangliomas. Lezi yizimila ezingavamile ezikhula ezinqeni ezithile futhi zikhiphe amanani amakhulu ama-hormone okucindezeleka njenge-adrenaline ne-noradrenaline. Uma lawa mahomoni ekhukhula ohlelweni lwakho, angabangela ukuthi umfutho wegazi wakho unyuke ngendlela eyingozi, okuholela ezimpawini ezinjengezinhlungu zekhanda ezinzima, ukushaya kwenhliziyo okusheshayo, nokujuluka ngokweqile.

Ngaphandle kwemibandela ehlobene nomdlavuza, odokotela ngezinye izikhathi banikeza i-phenoxybenzamine kwezinye izimo lapho imiphumela yokuvimba i-alpha ilungele khona. Lokhu kufaka phakathi izimo ezithile zomfutho wegazi ophezulu ongathobeli eminye imithi, futhi ngezinye izikhathi ngezimo ezithinta ukugeleza kwegazi emilenzeni. Kodwa-ke, lezi zindlela zokusebenzisa azivamile futhi zidinga ukugadwa ngokucophelela kwezokwelapha.

Kwezinye izikhungo zezokwelapha ezikhethekile, i-phenoxybenzamine ingase futhi isetshenziselwe ukulungiselela iziguli ukuhlinzwa uma zine-pheochromocytomas. Umuthi usiza ukuzinzisa umfutho wegazi ngaphambi kwenqubo yokususwa komdlavuza, ukunciphisa ingozi yokushintshashintsha okuyingozi komfutho wegazi ngesikhathi sokuhlinzwa.

Isebenza Kanjani I-Phenoxybenzamine?

I-Phenoxybenzamine isebenza ngokuvimba unomphela ama-alpha-adrenergic receptors emithanjeni yakho yegazi nakwezinye izicubu. La ma-receptors ngokuvamile aphendula ama-hormone okucindezeleka njenge-adrenaline ngokuqinisa imithambo yegazi nokwandisa izinga lokushaya kwenhliziyo. Lapho i-phenoxybenzamine ivimba la ma-receptors, imithambo yakho yegazi ingakhululeka futhi yande, ivumele igazi ukuthi ligeleze kalula futhi lehlise umfutho wegazi.

Lo muthi ubhekwa njenge-alpha-blocker eqinile futhi ehlala isikhathi eside. Ngokungafani neminye imithi yomfutho wegazi okudingeka ithathwe izikhathi eziningi ngosuku, imiphumela ye-phenoxybenzamine ingahlala izinsuku eziningana ngemva komthamo owodwa. Lokhu kuyenza isebenze ikakhulukazi ekuphatheni izimo lapho kudingeka khona i-alpha-blockade eqhubekayo, yesikhathi eside.

Isenzo somuthi asibuyiselwa emuva, okusho ukuthi uma sinamathisela kuma-alpha receptors, sihlala lapho kuze kube yilapho umzimba wakho ngokwemvelo ukhiqiza ama-receptors amasha. Le nqubo ngokuvamile ithatha amahora angu-24 kuya kwangu-48, okuchaza ukuthi kungani imiphumela yomuthi ihlala isikhathi eside kangaka nokuthi kungani ukulungiswa komthamo kudingeka kwenziwe kancane kancane.

Kufanele Ngiyithathe Kanjani I-Phenoxybenzamine?

Thatha i-phenoxybenzamine ngendlela eqondile njengoba uyalelwe udokotela wakho, ngokuvamile kanye noma kabili ngosuku ngaphandle kokudla noma ngaphandle kokudla. Gwinya amaphilisi wonke ngamanzi agcwele, futhi ungawachobozi, uwahlafune, noma uwaqhekeze. Ukuthatha imithi ngobisi noma ukudla okulula kungasiza ekunciphiseni isisu uma uhlangabezana nanoma yikuphi ukuphazamiseka kokugaya ukudla.

Kungenzeka ukuthi udokotela wakho uzoqala ngomthamo ophansi futhi awunyuse kancane kancane ezinsukwini ezimbalwa noma emasontweni ambalwa. Le ndlela eqaphelayo isiza umzimba wakho ukuthi ujwayele imithi futhi inciphisa imiphumela emibi efana nesiyezi noma ukukhathala. Ungaqomi imithamo noma uyeke ukuthatha imithi ngokuzumayo, ngoba lokhu kungabangela ukuthi umfutho wegazi lakho ukhuphuke ngendlela eyingozi.

Zama ukuthatha imithi yakho ngesikhathi esifanayo nsuku zonke ukuze ugcine amazinga aqhubekayo egazini lakho. Uma uyithatha kabili ngosuku, hlukanisa imithamo ngamahora ayi-12. Ukusetha isikhumbuzi sansuku zonke ocingweni lwakho kungakusiza ukuthi ukhumbule ukuthatha imithi yakho ngokuqhubekayo.

Ngesikhathi samasonto ambalwa okuqala okwelashwa, qaphela kakhulu lapho usukuma usuka ekuhlaliseni noma ekulaleni. Imithi ingabangela i-orthostatic hypotension, okusho ukuthi umfutho wegazi lakho ungase wehle lapho ushintsha izikhundla ngokushesha. Thatha isikhathi sakho ukuvuka futhi ubambe okuthile okuqinile uma uzizwa unesiyezi.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Phenoxybenzamine?

Ubude bokwelashwa nge-phenoxybenzamine buqondile ngesimo sakho esingaphansi kanye nokuhlolwa kukadokotela wakho. Kubantu abane-pheochromocytomas abalungiselela ukuhlinzwa, ukwelashwa kungase kuthatha amasonto ambalwa kuya ezinyangeni. Kodwa-ke, uma ukuhlinzwa kungenzeki noma uma unezinye izimo ezidinga i-alpha-blockade yesikhathi eside, ungase udinge ukuthatha le mithi iminyaka eminingi.

Udktela wakho uzoqapha njalo umfutho wegazi lakho, izinga lokushaya kwenhliziyo, kanye nokuphendula kwakho konke emuthini. Bazobheka futhi noma yimaphi imiphumela emibi futhi balungise umthamo wakho njengoba kudingeka. Ezinye iziguli zithola ukuthi umthamo wazo udinga ukukhushulwa ngokuhamba kwesikhathi ukuze kugcinwe ukusebenza kahle, kanti ezinye zihlala zizinzile emthamweni ofanayo isikhathi eside.

Ungayeki ukuthatha i-phenoxybenzamine ngokuzumayo ngaphandle kokubonisana nodokotela wakho kuqala. Ukuyeka kungazelelwe kungabangela umfutho wegazi ophezulu, okungaba yingozi. Uma udinga ukuyeka umuthi, udokotela wakho uzokwenza uhlelo lokunciphisa kancane umthamo wakho ngenkathi eqapha isimo sakho ngokucophelela.

Yini Imiphumela Emibi ye-Phenoxybenzamine?

Njengayo yonke imithi, i-phenoxybenzamine ingabangela imiphumela emibi, nakuba abantu abaningi beyibekezelela kahle uma umzimba wabo usujwayele. Imiphumela emibi evame kakhulu ihlobene nemiphumela yokwehlisa umfutho wegazi yomuthi futhi ngokuvamile iyathuthuka njengoba umzimba wakho ujwayela ukwelashwa.

Nansi imiphumela emibi evame kakhulu ongase uyithole:

• Isiyezi noma ukuzizwa unovalo, ikakhulukazi uma usukuma
• Ukukhathala noma ukuzizwa ukhathele ngokungavamile
• Ikhala elivaliwe noma eligelezayo
• Isicanucanu noma isisu esibuhlungu
• Ukozela noma ukuzizwa ulele
• Umlomo owomile
• Ukuqunjelwa

Le miphumela emibi evamile ivamise ukuncipha emasontweni ambalwa okuqala okwelashwa njengoba umzimba wakho ujwayela umuthi. Ukuhlala unamanzi kahle nokusukuma kancane ezindaweni zokuhlala noma zokulala kungasiza ekuphatheni isiyezi.

Imiphumela emibi engathi sína ayivamile kodwa idinga ukunakekelwa kwezokwelapha ngokushesha. Xhumana nodokotela wakho ngokushesha uma uthola isiyezi esibi esingathuthuki, izigameko zokuquleka, ukushaya kwenhliziyo okungajwayelekile, noma ubuhlungu besifuba. Ngaphezu kwalokho, uma uthola izimpawu zokungezwani komzimba nezinto ezithile njengokuqubuka, ukuluma, ukuvuvukala, noma ubunzima bokuphefumula, funa ukunakekelwa kwezokwelapha eziphuthumayo ngokushesha.

Ezinye iziguli zingase zibe nemiphumela engavamile efana nokudideka, ubunzima bokugxilisa ingqondo, noma izinguquko ekusebenzeni kocansi. Nakuba le miphumela ingase ikhathaze, ngokuvamile iyashintsheka futhi ivame ukuthuthuka ngokulungiswa komthamo noma ngesikhathi.

Ubani Ongafanele Athathe I-Phenoxybenzamine?

I-Phenoxybenzamine ayifanele wonke umuntu, futhi udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuyinika. Akufanele uthathe lo muthi uma wazi ukuthi unokungezwani komzimba ne-phenoxybenzamine noma yiziphi izithako zayo. Ngaphezu kwalokho, abantu abanezimo ezithile zenhliziyo, isifo esibi sezinso, noma umlando wokushaywa unhlangothi kungenzeka bangabi ngabantu abafanelekayo kulokhu kwelashwa.

Yazisa udokotela wakho ngazo zonke izimo zakho zezokwelapha ngaphambi kokuqala i-phenoxybenzamine. Lokhu kubaluleke kakhulu uma unesifo sikashukela, njengoba umuthi ungathinta amazinga kashukela egazini futhi ufihle ezinye izimpawu zikashukela ophansi. Abantu abanezimo zokuphefumula njenge-asthma noma isifo sokuvinjelwa kwamaphaphu esingapheli kufanele futhi baxoxe ngezingozi ezingase zibe khona nomhlinzeki wabo wezempilo.

Ukukhulelwa nokuncelisa ngamabele kudinga ukucatshangelwa okukhethekile nge-phenoxybenzamine. Nakuba kunedatha elinganiselwe ngobuphephile bayo ngesikhathi sokukhulelwa, umuthi kufanele usetshenziswe kuphela uma izinzuzo zizwela izingozi. Uma ukhulelwe, uhlela ukukhulelwa, noma uncelisa, xoxa ngokukhululekile nodokotela wakho mayelana nezinketho zokwelapha eziphephe kakhulu esimweni sakho.

Iziguli ezigugile zingase zizwele kakhulu imiphumela ye-phenoxybenzamine, ikakhulukazi izakhiwo zokwehlisa umfutho wegazi. Udokotela wakho angase aqale ngomthamo ophansi futhi akuqaphele eduze uma uneminyaka engaphezu kwengama-65.

Amagama Omkhiqizo we-Phenoxybenzamine

I-Phenoxybenzamine iyatholakala ngaphansi kwegama lomkhiqizo elithi Dibenzyline e-United States. Lena yindlela ejwayelekile kakhulu yokubhala futhi iza ngama-capsules angu-10mg. Ezinye izindawo zingase zibe namanye amagama omkhiqizo noma izinguqulo ezivamile ezitholakalayo, kodwa i-Dibenzyline ihlala ingumkhiqizo oyinhloko ezimakethe eziningi.

Izinguqulo ezivamile ze-phenoxybenzamine zingase zitholakale kwezinye izifunda, nakuba zingavamile ngenxa yokusetshenziswa okukhethekile komuthi. Njalo hlola nomkhemisi wakho ukuze uqinisekise ukuthi uthola umuthi ofanele kanye namandla abhalwe ngudokotela wakho.

Ezinye izindlela ze-Phenoxybenzamine

Ngenkathi i-phenoxybenzamine ivame ukuba yindlela yokwelapha ekhethwayo ye-pheochromocytomas, imithi eminingana ehlukile ingase icatshangelwe kuye ngesimo sakho esithile. I-Doxazosin, i-prazosin, ne-terazosin ezinye izivimbeli ze-alpha ezisebenza ngendlela efanayo kodwa zinesikhathi esifushane sokusebenza. Le mithi ingase ifaneleke uma ungakwazi ukubekezelela i-phenoxybenzamine noma uma isimo sakho singadingi ukuvinjwa kwe-alpha okuhlala isikhathi eside.

Izivimbeli ze-Beta ezifana ne-propranolol ngezinye izikhathi zisetshenziswa kanye nezivimbeli ze-alpha noma njengezinye izindlela ezimweni ezithile. Kodwa-ke, izivimbeli ze-beta akufanele neze zisetshenziswe zodwa ezigulini ezinama-pheochromocytomas, njengoba zingabangela ukwanda okuyingozi komfutho wegazi. Udokotela wakho uzoqoka inhlanganisela engcono kakhulu yemithi yezidingo zakho ngazinye.

Izivimbeli zesiteshi se-calcium ezifana ne-nifedipine noma i-amlodipine zingase zicatshangelwe njengokwelashwa okwengeziwe noma ezinye izindlela ezimweni ezithile. Le mithi isebenza ngendlela ehlukile ezivimbelini ze-alpha kodwa ingasiza futhi ekuphatheni umfutho wegazi futhi inciphise ezinye izimpawu ezihambisana ne-adrenaline eyeqile.

Ingabe i-Phenoxybenzamine ingcono kune-Doxazosin?

I-Phenoxybenzamine ne-doxazosin yomibili iyi-alpha-blockers, kodwa inamandla ahlukene nezicelo. I-Phenoxybenzamine ngokuvamile ithathwa njengephumelela kakhulu ekuphatheni ama-pheochromocytomas ngenxa yokubopha kwayo okungenakuguqulwa kanye nobude besikhathi sokusebenza. Lokhu kuyenza ibe yindlela ekhethwayo uma udinga i-alpha-blockade eqhubekayo, ehlala isikhathi eside.

Ngakolunye uhlangothi, i-Doxazosin inesikhathi esifushane sokusebenza kanye nokubopha okuguquguqukayo, okuyenza ilungele izimo ezinjenge-benign prostatic hyperplasia noma umfutho wegazi ophezulu ojwayelekile. Kulula futhi ukulungisa imithamo nge-doxazosin njengoba imiphumela yayo iphela ngokushesha kune-phenoxybenzamine.

Ukukhetha phakathi kwale mithi kuncike esimweni sakho esithile, izimpawu, kanye nemigomo yokwelapha. Udokotela wakho uzocabangela izinto ezinjengobunzima besimo sakho, ukusabela kwakho ekwelashweni kwangaphambilini, kanye nokubekezelela kwakho imiphumela emibi lapho enquma ukuthi iyiphi imithi engcono kuwe.

Imibuzo Evame Ukubuzwa Mayelana ne-Phenoxybenzamine

Ingabe i-Phenoxybenzamine iphephile kubantu abanezifo zenhliziyo?

I-Phenoxybenzamine ingasetshenziswa kubantu abanezifo zenhliziyo, kodwa idinga ukuqapha okucophelelayo nokulungiswa komthamo. Umuthi ungasiza ukunciphisa umsebenzi enhliziyweni yakho ngokwehlisa umfutho wegazi, okungaba usizo ezimweni ezithile zenhliziyo. Kodwa-ke, imiphumela yawo yokwehlisa umfutho wegazi ingaba yinkinga uma unezinhlobo ezithile zesifo senhliziyo noma uma umfutho wegazi wakho wehla kakhulu.

Udokotela wakho wenhliziyo nodokotela oqokayo bazosebenzisana ukuze banqume ukuthi i-phenoxybenzamine iphephile yini esimweni sakho senhliziyo esithile. Cishe bazoqala ngomthamo ophansi futhi bakuqaphele eduze nganoma yiziphi izimpawu zezinkinga zenhliziyo noma ukwehla okukhulu komfutho wegazi.

Ngingenzani uma ngiphuzile i-Phenoxybenzamine eningi ngengozi?

Uma ngabe uthatha i-phenoxybenzamine eningi kunaleyo oyinikiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha, ngisho noma ungezwa zimpawu ngokushesha. Ukweqisa kungabangela ukwehla okukhulu kwengcindezi yegazi, okungase kukwenze uzizwe unesiyezi kakhulu, ubuthakathaka, noma kukwenze uquleke.

Ungazami ukuzelapha ngokweqisa ngokuthatha eminye imithi noma izinto. Kunalokho, lala ngemilenze yakho iphakeme uma uzizwa unesiyezi, futhi funa ukunakekelwa kwezempilo ngokushesha. Uma othile engazi lutho noma enobunzima bokuphefumula ngemuva kokuthatha i-phenoxybenzamine eningi kakhulu, shayela izinsiza eziphuthumayo ngokushesha.

Kufanele Ngenzeni Uma Ngeqe Umthamo We-Phenoxybenzamine?

Uma weqa umthamo we-phenoxybenzamine, yithathe ngokushesha lapho ukhumbula, ngaphandle uma sekuseduze isikhathi somthamo wakho olandelayo. Kulokho, weqa umthamo owuqegile bese uqhubeka nohlelo lwakho lokulinganisa olujwayelekile. Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo owuqegile, ngoba lokhu kungabangela ukwehla okuyingozi kwengcindezi yegazi.

Ngenxa yokuthi i-phenoxybenzamine inemiphumela ehlala isikhathi eside, ukweqa umthamo owodwa ngokuvamile ngeke kubangele izinkinga ngokushesha. Kodwa-ke, zama ukugcina ukulinganisa okuqhubekayo ukuze ugcine ingcindezi yakho yegazi ilawulwa kahle. Uma uvame ukukhohlwa imithamo, cabangela ukusetha izikhumbuzi zocingo noma usebenzise umhleli wamaphilisi ukukusiza ukuthi ukhumbule.

Ngingayeka Nini Ukuthatha I-Phenoxybenzamine?

Kufanele uyeke kuphela ukuthatha i-phenoxybenzamine ngaphansi kokuqondisa nokuholwa ngudokotela wakho. Isikhathi sincike esimweni sakho esiyisisekelo kanye nemigomo yokwelashwa. Kubantu abalungiselela ukuhlinzwa kwe-pheochromocytoma, imithi ngokuvamile iyekiswa ngemuva kokuthi umdlavuza ususwe ngempumelelo futhi ingcindezi yegazi izinzile.

Udktela wakho uzokwakha uhlelo lokunciphisa kancane kancane kunokumisa imithi ngokushesha. Lokhu kusiza ekuvikeleni ukunyuka kwegazi eliphakeme futhi kuvumela umzimba wakho ukuthi uzivumelanise ngokuphepha. Bazogada umfutho wegazi lakho nezimpawu eduze ngesikhathi senqubo yokuyeka ukusebenzisa imithi ukuqinisekisa ukuphepha kwakho.

Ngingakwazi yini ukuphuza utshwala ngenkathi ngithatha i-Phenoxybenzamine?

Kungcono ukukhawulela noma ukugwema utshwala ngenkathi uthatha i-phenoxybenzamine, njengoba zombili izinto zinganciphisa umfutho wegazi. Ukuzihlanganisa kungakhuphula ingozi yakho yokuba nesiyezi, ukuquleka, nokwehla okuyingozi komfutho wegazi. Uma ukhetha ukuphuza utshwala, yenza kanjalo ngokulinganisela futhi uqaphele kakhulu ukusukuma ngokushesha noma ukuzibandakanya emisebenzini edinga ibhalansi eqinile.

Xoxa nodokotela wakho mayelana nokusetshenziswa kotshwala nesimo sakho esithile. Bangase batusa ukugwema utshwala ngokuphelele, ikakhulukazi emasontweni ambalwa okuqala okwelashwa lapho umzimba wakho usazivumelanisa nemithi. Njalo qinisekisa ukuphepha kwakho futhi ulandele izincomo zomnikezeli wakho wezempilo mayelana nokusebenzisana kotshwala nemithi.